Higher magnesium levels were negatively associated with DME after adjustment for relevant covariates. The serum magnesium and calcium levels were lower in the DME group than in the non-DME group (P < 0.05). Compared with the non-DME group, the DME group had a higher proportion of insulin use and a higher level of serum ischemia-modified albumin and fasting plasma glucose. All patients underwent a standardized clinical ophthalmic examination by an experienced ophthalmologist, and an assay was conducted to determine the serum magnesium concentration. A total of 519 such patients were included in this study. Patients with DR were recruited between January 2018 and June 2021. Here, we investigated the association between the serum magnesium levels and DME in patients with DR. Serum magnesium levels have been reported to reflect the risk of diabetic retinopathy (DR) however, the effect of serum magnesium level on diabetic macular edema (DME) remains unclear. This effect is mediated at least in part via the production of nitric oxide. The effect of MS is achieved after systemic and local peripheral administration and when MS is administered as a single drug in a single dose. ![]() Magnesium is a more effective anti-edematous drug in therapy than for preventing inflammatory edema. ![]() 01) reduced the anti-edematous effect of MS. 05), while in the highest tested dose L-NPA (2 mg/kg, P <. L-NAME, intraperitoneally administered before MS, potentiated (5 mg/kg, P <. 05) significantly prevented the development of inflammatory edema by 60%. MS administered systemically before or after inflammation reduced edema by 30% (5 mg/kg, P <. The effects of the nonselective inhibitor (L-NAME), selective inhibitor of neuronal (L-NPA) and inducible (SMT) nitric oxide synthase on the effects of MS were evaluated. In a rat model of carrageenan-induced paw inflammation, the anti-edematous activity of MS was assessed with a plethysmometer. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action. Magnesium is an antagonist of the N-methyl-D-aspartate receptor.
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